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Presumably, ineffective erythropoiesis due to dysplastic changes applies only to an AML subgroup (especially AML with myelodysplasia-related changes), whereas in other AML subtypes, insufficient erythropoiesis may rather be driven by other pathomechanisms as the suppression of erythropoiesis by inflammatory cytokines (44)

Dividing the total daily dose into two or three smaller doses taken with meals can significantly reduce gastrointestinal upset

Among other mechanisms, they slow gastric emptying and the motility of the small intestine, which helps limit post-meal blood sugar spikes

10.1093/toxsci/kfj111 [DOI] [PubMed] [Google Scholar] Klicek R., Kolenc D., Suran J., Drmic D., Brcic L., Aralica G., et al