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One of the biggest concerns with eating less and losing weight is the potential loss of lean muscle mass alongside body fat

10.1016/j.jnutbio.2007.06.010

Another study highlights that competitive uptake of extracellular glutamine by clear cell renal carcinoma activates hypoxia-inducible factor 1 (HIF-1) in tumor-infiltrating macrophages, inducing IL-23 secretion (81)