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Int J Mol Sci 14:38343859 Sami DH, Soliman AS, Khowailed AA, Hassanein EH, Kamel EM, Mahmoud AM (2022) 7-hydroxycoumarin modulates Nrf2/HO-1 and microRNA-34a/SIRT1 signaling and prevents cisplatin-induced oxidative stress, inflammation, and kidney injury in rats

Hydroxyl radical is an extremely reactive oxidant, which are generated as a result of interaction of H 2 O 2 with transition metal ions such as Fe 2+ or Cu 2+ (Fenton reaction) and O 2 (Haber-Weiss reaction) as well as from peroxynitrite which is rapidly formed via the reaction between NO and O 2 Hydrogen peroxide is formed through dismutation of O 2 catalyzed by the enzyme superoxide dismutase, and is also produced by several other oxidase enzymes (e.g

La N-acetilcistena (NAC) es una forma de aminocido que ayuda a mantener los niveles de glutatin, un antioxidante importante para el funcionamiento normal del cuerpo